Work

Pediatric anti‐ NMDA receptor encephalitis is seasonal

Year: 2014

Type: article

Abstract: In the majority of pediatric anti-N-methyl-d-aspartate receptor encephalitis (NMDARe) cases, the underlying cause of antibody production and subsequent disease remains unknown. We aimed to characterize this poorly understood population, investigating epidemiological factors potentially related to disease etiology, particularly season of onset. In this retrospective case review study, we analyzed data from the 29 pediatric subjects with anti-NMDAR antibodies and found that symptoms were first reported in the warm months of April-September in 78% of non-tumor-related NMDARe (NT-NMDARe) cases. These findings support further investigation into a possible seasonal trigger of NT-NMDARe.

Source: Annals of Clinical and Translational Neurology

DOI: 10.1002/acn3.100

Authors: Laura A. Adang, David R. Lynch, Jessica A. Panzer

Institutions: University of Pennsylvania, Children's Hospital of Philadelphia

Language: English

Topic: Autoimmune Neurological Disorders and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,100