Work

Poorly Differentiated Neuroendocrine Carcinoma of the Pancreas Responsive to Combination Therapy with Gemcitabine and S-1

Year: 2012

Type: article

Abstract: Poorly differentiated neuroendocrine carcinoma is a very rare malignancy, but it is characterized by agressive histological features and a poor clinical prognosis. We report a 42-year-old man who had poorly differentiated neuroendocrine carcinoma of the pancreas with multiple liver metastases. We administrated combined chemotherapy with S-1 and gemcitabine. This treatment was efficacious and well tolerated, and then this patient obtained objective partial response for 7 months and survived for 13 months after the diagnosis. This case suggests that S-1 and gemcitabine combination produce beneficial responses for patients with this disease.

Source: Internal Medicine

DOI: 10.2169/internalmedicine.51.6378

Authors: Mitsuyoshi Yamamoto, Koichiro Miyagawa, Masaaki Hiura, Masashi Taguchi, Yasuyuki Kihara, Shintaro Abe, Shohei Shimajiri, Masaru Harada

Institution: University of Occupational and Environmental Health Japan

Language: English

Topic: Neuroendocrine Tumor Research Advances

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2063673751

FWCI: 0.716

Cites: 30

Cited by: 7

Related to: 10