Work

Modified STING-activating cyclic dinucleotide derivatives significantly enhance the anti-tumor activity of therapeutic vaccines

Year: 2013

Type: conference-abstract

Abstract: Meeting abstracts The STING signaling pathway has emerged as a central TLR-independent mediator of host innate defense in response to sensing cytosolic nucleic acids, either through direct binding of CDNs secreted by intracellular bacteria, or through binding of a structurally distinct CDN produced

Source: Journal for ImmunoTherapy of Cancer

DOI: 10.1186/2051-1426-1-s1-o20

Authors: Meredith Leong, David Kanne, Laura Glickman, Edward Lemmens, Peter Lauer, Ken Metchette, Dara Burdette, Elie Diner, Juan Fu, Kevin Soares, Dirk Brockstedt, Daniel Portnoy, Russell Vance, Young Kim, Elizabeth Jaffee, Drew Pardoll, Thomas Dubensky

Institutions: Aduro BioTech (United States), University of California, Berkeley, Johns Hopkins University, Sidney Kimmel Cancer Center

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,490

OpenAlex ID: W2063736167

Cites:

Cited by: 2

Related to: 10