Double Umbilical Cord Blood Transplantation after Novel Myeloablative Conditioning Using FluBu4/TLI
Year: 2014
Type: article
Study design: Clinical Trial
Abstract: Double-unit umbilical cord blood transplantation (dCBT) is a validated strategy to broaden access to hematopoietic stem cell transplantation (HSCT), but is limited by delayed engraftment and immune reconstitution. ATG is a part of conventional myeloablative (MA) conditioning for CBT, and although it may facilitate engraftment, it can also contribute to delayed immune reconstitution through T-cell depletion. We conducted a Phase II trial to assess the safety and efficacy of dCBT following a preparative regimen combining total lymphoid irradiation (TLI, 400 cGy) in lieu of ATG, with Fludarabine/Busulfan 3.2mg/kg IV x4 (FluBu4).
Institutions: University of Michigan, Michigan Medicine, Henry Ford Hospital
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2063875272