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Monoclonal antibodies against the Drosophila nervous system.

Year: 1982

Type: article

Abstract: A panel of 148 monoclonal antibodies directed against Drosophila neural antigens has been prepared by using mice immunized with homogenates of Drosophila tissue. Antibodies were screened immunohistochemically on cryostat sections of fly heads. A large diversity of staining patterns was observed. Some antigens were broadly distributed among tissues; others were highly specific to nerve fibers, neuropil, muscle, the tracheal system, cell nuclei, photoreceptors, or other structures. The antigens for many of the antibodies have been identified on immunoblots. Monoclonal antibodies that identify specific molecules within the nervous system should prove useful in the study of the molecular genetics of neural development.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.79.24.7929

Authors: S C Fujita, S L Zipursky, S Benzer, A Ferrús, S L Shotwell

Institution: California Institute of Technology

Language: English

Topic: Neurobiology and Insect Physiology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: green

Funder: National Science Foundation

OpenAlex ID: W2063985696

FWCI: 3.003

Cites: 14

Cited by: 537

Related to: 10