Work

Assessing Interactions for Fixed-Dose Drug Combinations in Tumor Xenograft Studies

Year: 2012

Type: article

Abstract: Statistical methods for assessing the joint action of compounds administered in combination have been established for many years. However, there is little literature available on assessing the joint action of fixed-dose drug combinations in tumor xenograft experiments. Here an interaction index for fixed-dose two-drug combinations is proposed. Furthermore, a regression analysis is also discussed. Actual tumor xenograft data were analyzed to illustrate the proposed methods.

Source: Journal of Biopharmaceutical Statistics

DOI: 10.1080/10543406.2011.556285

Authors: Jianrong Wu, Lorraine Tracey, Andrew M. Davidoff

Institution: St. Jude Children's Research Hospital

Language: English

Topic: Statistical Methods in Clinical Trials

Subfield: Statistics and Probability

Field: Mathematics

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute