Year: 1985
Type: article
Abstract: During the past decade, an intense effort has been made to solve the major clinical problems affecting patients with Cooley's anemia and transfusional iron overload.'Parented chelation therapy has been introduced into regular use while investigations have continued to define the best methods for drug administration and to monitor the changes in excess iron load and organ function that occur during treatment.Blood products have been modified in an attempt to prolong the survival of transfused red cells and to reduce the rate of iron loading.The overall goal has been to prevent the accumulation of excessive iron that leads to early death.We have previously reported marked reductions in Serum ferritin concentration and hepatic iron content to normal or near-normal levels in four children with Cooley's anemia after intensive chelation therapy with deferoxamine (DFO)?-'In this paper, we summarize the subsequent course of this group.In addition, we describe the results of treatment of iron overload in our total program, where all patients are Seen regularly by the same physicians or nurse practitioner and where, with few exceptions, a uniform treatment regimen has been instituted.
Authors: A. COHEN, J. MIZANIN, E. SCHWARTZ
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funder: National Institutes of Health
OpenAlex ID: W2064338623