Re: Allogeneic transplantation after nonmyelosuppressive conditioning—the effect of single-agent pentostatin
Year: 2004
Type: letter
Abstract: Reduced-intensity preparative regimens for allogeneic transplantation have been used to provide sufficient immunosuppression to allow for successful donor engraftment. In a recent article by Chan et al. [1], 18 patients with myelodysplasia underwent allogeneic progenitor cell transplantation with a novel preparative regimen of extracorporeal photopheresis, total body irradiation, and pentostatin. The pentostatin was given by continuous infusion over 2 days at 4 mg/m2. The relative contribution of each agent in achieving immunosuppression of the donor was not assessed. Recent work suggests that successful nonmyeloablative regimens may be developed free of total body irradiation and that single-agent pentostatin may be sufficient to achieve donor chimerism.
Authors: Gary J. Schiller, Rose Malone, Robert Figlin
Institution: University of California, Los Angeles
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2064351962