30: A Fully-Human Chimeric Antigen Receptor for Redirecting Specificity of T Cells to B-Lineage Tumors
Year: 2008
Type: article
Abstract: Adoptive therapy after allogeneic hematopoietic stem-cell transplantation with ex vivo-expanded donor-derived tumor-specific T cells to augment the graft-versus-leukemia (GVL) effect might be used to reduce the incidence of leukemic relapse without exacerbating graft-versus-host disease. We previously showed that genetically modified peripheral- and umbilical cord blood-derived T cells rendered specific for CD19, a molecule constitutively expressed on B-cell malignancies can augment GVL-effect. The redirected specificity was achieved by electro-transfer of a DNA plasmid coding for the chimeric antigen receptor (CAR) that recognizes CD19 via the scFv of a murine CD19-specific monoclonal antibody (mAb) fused to T-cell activation endodomains.
Institution: The University of Texas MD Anderson Cancer Center
Language: English
Topic: CAR-T cell therapy research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2064425181