Work

Polymorphisms in DNA damage response genes and head and neck cancer risk

Year: 2010

Type: article

Study designs: Systematic Review, Meta-Analysis

Abstract: BACKGROUND: Polymorphisms in DNA repair genes have been reported contributing factors in head and neck cancer risk but studies have shown conflicting results. OBJECTIVE: To clarify the impact of DNA repair gene polymorphisms in head and neck cancer risk. METHOD: A meta-analysis including 30 case-control studies was performed. RESULTS: Marginally statistically significant association was found for XRCC1 codon 399 (for Caucasians only), XPD Asp312Asn and XRCC1 codon 194 variants and head and neck cancer. CONCLUSION: Assessments of the effects of smoking, alcohol, human papillomavirus and race/ethnicity on the association between DNA repair gene polymorphisms and head and neck cancer are needed.

Source: Biomarkers

DOI: 10.3109/13547501003797664

Authors: Rafael E. Flores-Obando, Susanne M. Gollin, Camille C. Ragin

Institutions: State University of New York, SUNY Downstate Health Sciences University, University of Pittsburgh, UPMC Hillman Cancer Center

Language: English

Topic: Head and Neck Cancer Studies

Subfield: Otorhinolaryngology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green