Neutralizing Antibodies to Hepatitis C Virus in Perinatally Infected Children Followed Up Prospectively
Year: 2011
Type: article
Study design: Observational Study
Abstract: Little is known about the presence and role of neutralizing antibodies (NtAbs) in perinatal hepatitis C virus (HCV) infection. Using HCV pseudoparticles, NtAbs were studied longitudinally in 12 HCV-infected children with or without evidence of acute hepatitis during the first year of life. Broadly reactive NtAbs of maternal origin did not prevent vertical HCV transmission or progression to chronicity. NtAbs against homologous genotype or subtype appeared during the chronic phase and were more abundant and sustained in children with acute hepatitis. Cross-reactive NtAbs were present in both groups of children, but their appearance did not correlate with better control of viremia or HCV clearance.
Institutions: National Institutes of Health, National Institute of Allergy and Infectious Diseases, University of Copenhagen, Hvidovre Hospital, Copenhagen University Hospital, University of Cagliari, University of Turin, Sapienza University of Rome, Federico II University Hospital, University of Naples Federico II
Language: English
Topic: Hepatitis C virus research
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funder: National Institutes of Health
OpenAlex ID: W2064438058