Work

TCR Transduction Approach to Expand Severe Graft-Versus-Host Disease Inducing CD4 Specific T Cells

Year: 2012

Type: article

Abstract: Allogeneic hematopoietic cell transplantation (HCT) remains the most promising curative therapy for the treatment of hematological malignancies, but is complicated by the development of graft-versus-host disease (GVHD), mediated by donor T cells targeted against either HLA or minor histocompatibility antigens (miHA) of the host. CD4 T cells recognizing certain miHA have been found capable of mediating severe GVHD on their own in some murine models. Previous studies have utilized CDR3-size spectratyping to identify a unique population of CD4+Vβ11+ T cells that have subsequently been shown capable of infiltrating both the rete-like prominences of the dorsal lingual epithelium and the ileal crypts of the small intestine while mediating lethal GVHD in the miHA disparate C57BL/6 (B6) → C.B10-H2b/LiMcdJ (BALB.B) transplantation model.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2011.12.434

Authors: J. Matos, M. Appel, R. Korngold, T. Friedman

Institution: Hackensack University Medical Center

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650