Work

Sepsis-induced lung fibrosis in baboons is reduced by the treatment with a complement inhibitor

Year: 2011

Type: article

Abstract: Pulmonary fibrosis is a major and common medical condition, characterized by progressive scaring and decline in lung function. Persistent inflammation and acute lung injury in response to sepsis are potential triggers of the fibrotic response. Recently, we have reported that Escherichia coli sepsis in baboons strongly induces procoagulant responses and affects the integrity of the lung. These effects are diminished by the treatment with compstatin, a C3 convertase complement inhibitor [ 1 ].

Source: Critical Care

DOI: 10.1186/cc10403