Work

Early donor lymphocyte infusion (DLI) does not consistently prevent graft rejection in dogs given DLA-identical marrows after 1 Gy total body irradiation (TBI)

Year: 2006

Type: article

Abstract: Background: Secondary graft rejections may occur after nonmyeloablative conditioning for hematopoietic cell transplantation (HCT), particularly in patients with chronic myeloid leukemia given unrelated grafts (Biol Blood Marrow Transplant. 2005;11:272). We have shown that low (<50%) donor T-cell and NK cell chimerism levels on day 14 after HCT predicted graft rejection (Blood. 2004;104:2254). Here we investigated in a pre-clinical canine model of HCT, whether pre-emptive DLI given 1 month after HCT could prevent secondary graft rejection that was the rule in dogs given DLA-identical marrow after suboptimal conditioning with 1 Gy TBI and postgrafting immunosuppression with cyclosporine (CSP) combined with either mycophenolate mofetil (MMF) or rapamycin (11 of 11 dogs experienced graft rejection by wk 12).

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2005.11.170

Authors: F. Baron, B. Sandmaier, E. Zellmer, M. Sorror, M.T. Little, R. Storb

Institution: Fred Hutch Cancer Center

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650