Work

Chronic inositol treatment reduces depression-like immobility of Flinders Sensitive Line rats in the forced swim test

Year: 2002

Type: article

Abstract: Inositol, a precursor of the PIP cycle that was reported to have therapeutic effects in depressive patients and to be effective in two animal models of depression, was evaluated in the forced swim test using the genetic Flinders Sensitive Line (FSL) rats model of depression. Groups of rats were tested in a 2 x 2 design with Strain (FSL or Control) as one factor and Drug (Inositol or Placebo) as the second factor. Rats received chronic treatment (daily for 14 days) with inositol (1.2 g/kg) or placebo (1:2 glucose/mannitol solution). On day 14 rats were exposed to the forced swim test for 5 min and their behavior videotaped. Tapes were analyzed for three levels of activity: immobility, swimming, and vigorous struggle. Inositol countered the exaggerated immobility of FSL rats in the forced swim test, without affecting control animals. Data support our previous suggestion of inositol as a potential antidepressant.

Source: Depression and Anxiety

DOI: 10.1002/da.10025

Authors: Haim Einat, Robert H. Belmaker, Avraham Zangen, D.H. Overstreet, Gal Yadid

Institutions: Ben-Gurion University of the Negev, University of North Carolina at Chapel Hill, Bar-Ilan University

Language: English

Topic: Treatment of Major Depression

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2064568619

FWCI: 0.808

Cites: 24

Cited by: 22

Related to: 10