Work

Delayed Onset, Protracted Delirium and Aspiration Pneumonitis Associated with a Combination of Clozapine and Electroconvulsive Therapy

Year: 2011

Type: article

Abstract: Few studies reported the efficacy and safety in combination of clozapine and electroconvulsive therapy (ECT) in schizophrenia; systematic studies are lacking. Side effects like seizure, and confusional state are reported. Authors report two cases of delayed onset/protracted delirium with ECT and clozapine in schizophrenia, one of whom developed aspiration pneumonitis possibly due to clozapine hyper-salivation. Delirium improved with stopping of ECT and clozapine. Clozapine monotherapy restarted to previous dosages in both cases without recurrence of delirium. Authors recommend for careful monitoring for delirium in ECT augmentation on high dose clozapine. Unilateral ECT may be preferred for augmenting clozapine.

Source: Indian Journal of Psychological Medicine

DOI: 10.4103/0253-7176.85402

Authors: N. Manjunatha, G. S. Ram Kumar, R. Vidyendaran, K. Muralidharan, J. P. John

Institution: National Institute of Mental Health and Neurosciences

Language: English

Topic: Electroconvulsive Therapy Studies

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2064670932

FWCI:

Cites: 15

Cited by: 13

Related to: 10