Delaying a Treatment Switch in Antiretroviral-Treated HIV Type 1-Infected Patients with Detectable Drug-Resistant Viremia Does Not Have a Profound Effect on Immune Parameters: AIDS Clinical Trials Group Study A5115
Year: 2009
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Some patients are unable to achieve and maintain an undetectable plasma HIV-1 RNA level with combination antiretroviral therapy (ART) and are therefore maintained on a partially suppressive regimen. To determine the immune consequences of continuing ART despite persistent viremia, we randomized 47 ART-treated individuals with low to moderate plasma HIV-1 RNA levels (200-9999 copies/ml) to either an immediate switch in therapy or a delayed switch (when plasma HIV-1 RNA became > or =10,000 copies/ml). After 48 weeks of follow-up, naive and memory CD4+ T cell percents were comparable in the two groups. The proportion of subjects with a lymphocyte proliferative response to Candida, Mycobacterium avium-intracellulare complex, or HIV-gag was also not significantly different at week 48. Delaying a treatment switch in patients with partial virologic suppression and stable CD4+ T cells does not have profound effects on immune parameters.
Institutions: Rush University Medical Center, Rush University, Harvard University, Social and Scientific Systems (United States), Brigham and Women's Hospital, Duke Medical Center, San Francisco General Hospital, University of California, San Francisco, University of California San Francisco Medical Center, University of Pittsburgh
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Awards: HIV-1 Therapeutics and Drug Resistance, G2027736814, AIDS Clinical Trials Group Network, STATISTICAL AND DATA MANAGEMENT CENTER, G3810609436, Northwestern University Clinical Trial Unit, International Clinical Trials Unit, University of Pittsburgh Clinical Trials Unit, ADULT ACTG CENTRAL GROUP, Statistical and Data Management Center for the AIDS Clinical Trials Group, Partners Healthcare Systems/Harvard Medical School/Boston Medical Center AIDS CTU, K24 MID-CAREER CLINICAL INVESTIGATOR AWARD, HIV/AIDS Clinical Trials Unit, Center for AIDS Research
OpenAlex ID: W2064705631