Work

Cardiac Cryolesions as an Experimental Model of Myocardial Wound Healing

Year: 1987

Type: article

Abstract: The standard coronary ligation model for experimental myocardial infarction results in variable areas and patterns of necrosis; therefore, the healing of such infarctions is also variable. The authors developed an experimental myocardial injury model using simple cryoinjury, which allows standardization of the size, depth, and location of the wound. Thirty-eight left ventricular cryolesions were created in 19 dogs, which were then killed from 3 to 35 days after injury. A consistent decrease in the depth of scar (p less than 0.005) and accumulation of collagen (p less than 0.0001) over time characterized this healing myocardial wound. Histologic examination revealed that the cellular pattern of healing myocardial cryolesions is similar to that of a healing myocardial infarction but with less variability. The authors advocate the use of cardiac cryolesions as a model of experimental myocardial wound healing.

Source: Annals of Surgery

DOI: 10.1097/00000658-198712000-00019

Authors: J. ARTHUR JENSEN, JON C. KOSEK, THOMAS K. HUNT, WILLIAM H. GOODSON, D. CRAIG MILLER

Institutions: University of California, San Francisco, Stanford Medicine, Stanford University

Language: English

Topic: Cardiac Fibrosis and Remodeling

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2064772732

FWCI:

Cites: 9

Cited by: 35

Related to: 10