Work

Direct Monte Carlo computation of time-resolved fluorescence in heterogeneous turbid media

Year: 2012

Type: article

Abstract: We show that a multiexponential model for time-resolved fluorescence allows the use of an absorption-perturbation Monte Carlo (MC) approach based on stored photon path histories. This enables the rapid fitting of fluorescence yield, lifetimes, and background tissue absorptions in complex heterogeneous media within a few seconds, without the need for temporal convolutions or MC recalculation of photon path lengths. We validate this method using simulations with both a slab and a heterogeneous model of the mouse head.

Source: Optics Letters

DOI: 10.1364/ol.37.004783

Author: Anand T. N. Kumar

Institutions: Harvard University, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging

Language: English

Topic: Optical Imaging and Spectroscopy Techniques

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

Open Access status: bronze

Funders: National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering

Awards: G3024975283, G9000155280