Work

Platelets and metastasis revisited: a novel fatty link

Year: 2004

Type: article

Abstract: Platelets have long been suspected of having a role in cancer progression and metastasis that has largely been attributed to platelet-mediated enhancement of tumor cell survival, extravasation, and angiogenesis. A study in this issue of the JCI suggests that platelet-derived lysophosphatidic acid is coopted by aggressive breast and ovarian cancer cells as a tumor cell mitogen and promoter of osteolysis during bone metastasis.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci200423823

Authors: Gaorav P. Gupta, Joan Massagué

Institutions: Memorial Sloan Kettering Cancer Center, Howard Hughes Medical Institute

Language: English

Topic: Sphingolipid Metabolism and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2064919555

FWCI: 2.633

Cites: 19

Cited by: 134

Related to: 10