Work

Osteogenic sarcoma in the Rothmund-Thomson syndrome

Year: 1996

Type: article

Abstract: Two children who had the Rothmund-Thomson syndrome and developed osteosarcoma are reported. The 10 previously reported cases are reviewed. The osteosarcomas developed at a younger age than normally expected and 66% occurred in the tibia/fibula. Four of the five patients for whom information was available showed undue sensitivity to cancer chemotherapy agents with prolonged myelosuppression and severe mucositis. It is recommended that doxorubicin in particular should be given with extreme caution in such patients.

Source: Medical and Pediatric Oncology

DOI: 10.1002/(sici)1096-911x(199604)26:4<249::aid-mpo5>3.0.co;2-j

Authors: Andrea Leonard, Alan W. Craft, Celia Moss, Archie J. Malcolm

Institutions: Newcastle University, Royal Victoria Infirmary, Birmingham Children's Hospital

Language: English

Topic: Sarcoma Diagnosis and Treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2064942973

FWCI: 2.423

Cites: 20

Cited by: 39

Related to: 10