Work

Do changes in the c-MYC coding sequence contribute to tumorigenesis?

Year: 2014

Type: article

Abstract: The role of changes in the c-MYC coding sequence in cancer is controversial. Overexpression of wild-type protein is sufficient to drive tumorigenesis, yet point mutations in c-MYC are common in Burkitt's lymphoma. Our discovery that disparate tumor-associated mutations in c-MYC have similar protumorigenic effects suggests that these mutations contribute directly to malignancy.

Source: Molecular & Cellular Oncology

DOI: 10.4161/23723548.2014.965631

Authors: Abhishek A. Chakraborty, William P. Tansey

Institutions: Brigham and Women's Hospital, Vanderbilt University, Dana-Farber Cancer Institute, Dana-Farber Brigham Cancer Center

Language: English

Topic: Cancer-related Molecular Pathways

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $1,590