Work

Synthetic Biology of Multicellular Systems: New Platforms and Applications for Animal Cells and Organisms

Year: 2014

Type: editorial

Abstract: Like life itself, synthetic biology began with unicellular \norganisms. Early synthetic biologists built genetic circuits \nin model prokaryotes and yeast because of their relative \nbiological simplicity and ease of genetic manipulation. With \nsuperior genetic tools, faster generation times, and betterunderstood endogenous gene expression machinery, prokaryotes and yeast were (and remain) appealing hosts for the engineering of synthetic systems. Now in its second decade, synthetic biology in unicellular organisms has produced myriad synthetic genetic circuits, a number of industrial applications, and fundamental new biological insights unlikely to have emerged from nonsynthetic approaches.

Source: ACS Synthetic Biology

DOI: 10.1021/sb500358y

Authors: Joseph S. Markson, Michael B. Elowitz

Institutions: California Institute of Technology, Howard Hughes Medical Institute

Language: English

Topic: Gene Regulatory Network Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Howard Hughes Medical Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Award: Bottom-up reconstitution of BMP morphogenetic pattern formation

OpenAlex ID: W2065054759

Cites: 2

Cited by: 18

Related to: 10