Work

Gold Nanoparticle–Fluorophore Complexes: Sensitive and Discerning “Noses” for Biosystems Sensing

Year: 2010

Type: review

Abstract: Gold nanoparticles (NPs) efficiently quench adsorbed fluorophores. Upon disruption of such complexes by an analyte, fluorescence turn-on is observed. By judicious choice of the functionalized NP and the fluorophore, these complexes display different responses to analytes, thus leading to versatile yet simple array-based sensor platforms. Using this strategy, we can identify proteins in buffer and serum, distinguish between both different species and different strains of bacteria, and differentiate between healthy, cancerous, and metastatic human and murine cells.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.200906928

Authors: Uwe H. F. Bunz, Vincent M. Rotello

Institutions: Georgia Institute of Technology, University of Massachusetts Amherst

Language: English

Topic: Gold and Silver Nanoparticles Synthesis and Applications

Subfield: Electronic, Optical and Magnetic Materials

Field: Materials Science

Domain: Physical Sciences

Open Access status: green

Funders: National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases

Awards: Detection of Bacteria using Nanoparticle-Polymer Sensors, Rapid Multi-Channel Serum Profiling for Cardiac Disease using Fluorescent Nanosensors