Work

Tumor resistance to apoptosis

Year: 2008

Type: review

Abstract: One of the hallmarks of human cancers is the intrinsic or acquired resistance to apoptosis. Evasion of apoptosis may contribute to carcinogenesis, tumor progression and also to treatment resistance, since most current anticancer therapies including chemotherapy, radio- and immunotherapy primarily act by activating cell death pathways including apoptosis in cancer cells. Hence, a better understanding of the molecular mechanisms underlying tumor resistance to apoptotic cell death is expected to provide the basis for a rational approach to develop molecular targeted therapies.

Source: International Journal of Cancer

DOI: 10.1002/ijc.24064

Author: Simone Fulda

Institution: Universität Ulm

Language: English

Topic: Cell death mechanisms and regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Deutscher Akademischer Austauschdienst, Deutsche Forschungsgemeinschaft, Deutsche Krebshilfe, Institut National Du Cancer