Year: 2005
Type: article
Abstract: In broad terms, there are 3 types of cardiac hypertrophy: normal growth, growth induced by physical conditioning (i.e., physiologic hypertrophy), and growth induced by pathologic stimuli. Recent evidence suggests that normal and exercise-induced cardiac growth are regulated in large part by the growth hormone/IGF axis via signaling through the PI3K/Akt pathway. In contrast, pathological or reactive cardiac growth is triggered by autocrine and paracrine neurohormonal factors released during biomechanical stress that signal through the Gq/phospholipase C pathway, leading to an increase in cytosolic calcium and activation of PKC. Here we review recent developments in the area of these cardiotrophic kinases, highlighting the utility of animal models that are helping to identify molecular targets in the human condition.
DOI: 10.1172/jci200524178
Authors: Gerald W. Dorn, Thomas Force
Institutions: University of Cincinnati, Tufts University, Tufts Medical Center
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G1070555374, G1292567896, G1373164301, G2123473406, Signaling Processes Underlying Cardiovascular Function, SCOR IN SUDDEN CARDIAC DEATH, Cytosolic Phospholipase A2 in Cardiac Hypertrophy, G534290876, G5786588766, Signaling Mechanisms Governing Cardiac Hypertrophy, MITOCHONDRIAL FUSION FACTORS AND CARDIOMYOPATHY, PHOSPHOLIPASE C AND CARDIAC HYPERTROPHY
OpenAlex ID: W2065417808