Work

Osteophilic Multilayer Coatings for Accelerated Bone Tissue Growth

Year: 2012

Type: article

Abstract: Osteophilic modular nanostructured multilayers containing hydroxyapatite nanoparticles complexed with a natural polymer chitosan create an osteoconductive surface for mesenchymal stem cells (MSCs). Coupled with the sustained release of physiological amounts of osteoinductive bone morphogenetic protein over several days from degradable poly(β-amino ester) based multilayers, this single coating results in a synergistic accelerated and upregulated differentiation of MSCs into osteoblasts laying down new bone tissue on orthopedic implants.

Source: Advanced Materials

DOI: 10.1002/adma.201104475

Authors: Nisarg J. Shah, Jinkee Hong, Md. Nasim Hyder, Paula T. Hammond

Institutions: Institute for Soldier Nanotechnologies, Koch Institute for Integrative Cancer Research At MIT, Massachusetts Institute of Technology

Language: English

Topic: Bone Tissue Engineering Materials

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green