Work

Nucleotide sequence of a plasmid-encoded hemolysin determinant and its comparison with a corresponding chromosomal hemolysin sequence

Year: 1986

Type: article

Abstract: The complete sequence of the plasmid pHly152-encoded hemolysin (hly) determinant of Escherichia coli is presented and compared with a recently sequenced chromosomal hly determinant [1]. High sequence homology between the two hly determinants is observed withìn all four structural genes, hlyC, A, B and D, but little sequence similarities are found in the 3′- and 5′-noncoding flanking regions. In addition, the noncoding region upstream of hlyC which carries the promoter for hlyC, A and B, was sequenced for several chromosomal hly determinants. The comparison of these sequences indicates three distinct classes of promoter regions which share common putative −10 and −35 boxes at roughly the same location relative to the start of hlyC.

Source: FEMS Microbiology Letters

DOI: 10.1016/0378-1097(86)90261-2

Authors: J. Hess, W. Wels, M. Vogel, W. Goebel

Institution: University of Würzburg

Language: English

Topic: Escherichia coli research studies

Subfield: Endocrinology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funder: Deutsche Forschungsgemeinschaft

Award: G5039202075