Work

A Structural Perspective on the Where, How, Why, and What of Nucleosome Positioning

Year: 2010

Type: review

Abstract: The DNA in eukaryotic chromatin is packed by histones into arrays of repeating units called nucleosomes. Each nucleosome contains a nucleosome core, where the DNA is wrapped around a histone octamer, and a stretch of relatively unconstrained DNA called the linker DNA. Since nucleosome cores occlude the DNA from many DNA-binding factors, their positions provide important clues for understanding chromatin packing and gene regulation. Here we review the recent advances in the genome-wide mapping of nucleosome positions, the molecular and structural determinants of nucleosome positioning, and the importance of nucleosome positioning in chromatin higher order folding and transcriptional regulation.

Source: Journal of Biomolecular Structure and Dynamics

DOI: 10.1080/07391102.2010.10508585

Authors: Gaurav Arya, Arijit Maitra, Sergei A. Grigoryev

Institutions: University of California San Diego, Pennsylvania State University, Penn State Milton S. Hershey Medical Center

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W2065441847

FWCI: 0.904

Cites: 126

Cited by: 60

Related to: 10