Work

Neighboring group effects in the regioselective cyclization of vicinal trans-1,2-bromohydrins to epoxides

Year: 1998

Type: article

Abstract: Bromocyclopentitols and amino (or amido) bromocyclopentitols having a CBr bond trans to two different vicinal hydroxyl groups show selectivity in base-promoted epoxide formation. The role of adjacent polar substituents in directing bromohydrin cyclization is discussed.

Source: Tetrahedron Letters

DOI: 10.1016/s0040-4039(98)01243-x

Authors: Fengrui Lang, Darren J Kassab, Bruce Ganem

Institution: Cornell University

Language: English

Topic: Organic Chemistry Synthesis Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $3,610

Funder: National Institutes of Health