Poly(2‐oxazoline)s as Polymer Therapeutics
Year: 2012
Type: article
Abstract: Poly(2-oxazoline)s (POx) are currently discussed as an upcoming polymer platform for biomaterials design and especially for polymer therapeutics. POx meet specific requirements needed for the development of next-generation polymer therapeutics such as biocompatibility, high modulation of solubility, variation of size, architecture as well as chemical functionality. Although in the early 1990s first and promising POx-based systems were presented, the field lay dormant for almost two decades. Only very recently, POx-based polymer therapeutics came back into the focus of very intensive research. In this review, we give an overview on the chemistry and physicochemical properties of POx and summarize the research of POx-protein conjugates, POx-drug conjugates, POx-based polyplexes and POx micelles for drug delivery.
Authors: Robert Luxenhofer, Yingchao Han, Anita Schulz, Jing Tong, Zhijian He, Alexander V. Kabanov, Rainer Jordan
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
Awards: G3198995655, G3707875540, G6549370615
OpenAlex ID: W2065735911