Work

Reduction of Pten dose leads to neoplastic development in multiple organs of Pten shRNA mice

Year: 2010

Type: article

Abstract: To address the impact of partial reduction of Pten on tumor initiation, we generated PtenshRNA mice, in which PTEN expression was reduced below normal levels in various tissues. PtenshRNA mice frequently developed lymphoid and prostatic hyperplasia, splenomegaly, and sebaceous adenomas. Our observations support the notion that partial reduction of the dose of Pten with shRNA is sufficient to induce neoplastic disease in multiple organ systems.

Source: Cancer Biology & Therapy

DOI: 10.4161/cbt.10.11.13814

Authors: Hong Shen-Li, Susan Koujak, Matthias Szablocs, Ramon Parsons

Institution: Columbia University Irving Medical Center

Language: English

Topic: PI3K/AKT/mTOR signaling in cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Cancer Institute