Work

Pdcd4 targets eIF4A to inhibit translation, transcription, tumorigenesis, and invasion

Year: 2006

Type: article

Abstract: preproGRP transcripts were found in 28% of the blood samples.The detection of a hematogenic tumor cell spread with preproGRP in MTC correlated significantly with advanced tumor categories.CK20 transcripts were detected in 75% of the blood samples of patients with thyroid carcinoma and distant metastases.Moreover disseminated tumor cells were detected in 21% of the bone marrow samples with CK20-PCR and 13% with preproGRP (only for MTC).Conclusion: Both assays are sensitive enough to detect disseminated thyroid carcinoma cells in blood and bone marrow samples.However, the prognostic relevance of these disseminated tumor cells is not completely understood and has to be addressed in further investigations.

Source: European Journal of Cancer Supplements

DOI: 10.1016/j.ejcsup.2006.04.053

Authors: Nancy H. Colburn, Hsin-Sheng Yang, Aaron Jansen

Institution: National Cancer Institute

Language: English

Topic: Mechanisms of cancer metastasis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

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