Year: 2013
Type: peer-review
Abstract: We thank Dr Messerli and colleagues for their interest in the extended follow-up of the lipid-lowering component of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). The long-term benefit of pravastatin on coronary heart disease (CHD) mortality and combined fatal/nonfatal CHD in black participants was statistically significant and consistent with the benefit observed for fatal/nonfatal CHD during the trial. In contrast, the elevated risk for stroke mortality in blacks was nonsignificant as was the in-trial risk for stroke for the entire ALLHAT black cohort (hazard ratio 1.12, 95% confidence interval [CI], 0.86–1.48 vs 0.74, 95% CI, 0.57–0.96 in non-blacks). During the extended follow-up there was a nonsignificantly higher risk in blacks and a nonsignificantly lower risk in non-blacks for both kidney disease mortality and end-stage renal disease in the pravastatin group compared to usual care. Although this finding was not seen during the trial and could have arisen simply by chance as a result of multiple comparisons, a potential differential effect of statins on renal outcomes in blacks and non-blacks should be investigated in other long-term outcome studies. Further analyses of the ALLHAT data, including additional extended follow-up of the ALLHAT participants, may also prove informative.
Source: Journal of Clinical Hypertension
DOI: 10.1111/jch.12220
Authors: Karen L. Margolis, Barry R. Davis, Charles Baimbridge, Jerry O. Ciocon, Aloysius B. Cuyjet, Richard A. Dart, Paula T. Einhorn, Charles E. Ford, David Gordon, Thomas J. Hartney, L. Julian Haywood, Jordan Holtzman, David E. Mathis, Suzanne Oparil, Jeffrey L. Probstfield, Lara M. Simpson, John D. Stokes, Thomas B. Wiegmann, Jeff D. Williamson
Institutions: HealthPartners, Cleveland Clinic Florida, Nassau University Medical Center, Stony Brook University, Marshfield Clinic Research Foundation, Marshfield Clinic Research Institute, National Heart, Lung, and Blood Institute, United States Department of Veterans Affairs, Charlie Norwood VA Medical Center, University of Southern California, Minneapolis VA Medical Center, Mercer University, University of Alabama at Birmingham, University of Washington Medical Center, Kansas City VA Medical Center, Wake Forest University Health Sciences, Wake Forest University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2066015657