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Achromatic miniature lens system for coherent Raman scattering microscopy

Year: 2013
Type: article
Abstract: We discuss the design and performance of a miniature objective lens optimized for coherent Raman scattering microscopy. The packaged lens assembly has a numerical aperture of 0.51 in water and an outer diameter of 8 mm. The lens system exhibits minimum chromatic aberrations, and produces coherent Raman scattering images with sub-micrometer lateral resolution (0.648 μm) using near-infrared excitation pulses. We demonstrate that despite the small dimensions of the miniature objective, the performance of this lens system is comparable to standard microscope objective lenses, offering opportunities for miniaturizing coherent Raman scattering imaging probes without sacrificing the image quality.
DOI: 10.1364/boe.4.002196
Language: English
Subfield: Biophysics
Open Access status: gold
Estimated APC paid: $1,913
Funders: American Society for Laser Medicine and Surgery, National Institutes of Health, National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering, National Center for Research Resources, Air Force Office of Scientific Research
Awards: G1523888516, G3614536702, G4101626806, A Laser Microbeam Biotechnology Resource, A Virtual Tissue Simulator for Biomedical Optics, A Laser Microbeam Biotechnology Resource, G811065503, G9000177675, G9000376361, Cancer Center Support Grant
OpenAlex ID: W2066067819
FWCI: 0.404
Cites: 30
Cited by: 8
Related to: 10