Work

Analysis of JAK3, JAK2, and C-MPL mutations in transient myeloproliferative disorder and myeloid leukemia of Down syndrome blasts in children with Down syndrome

Year: 2007

Type: article

Abstract: vascular endothelial cells would normally prevent inappropriate adhesion and enhance mobility.We therefore propose that our results reflect an impaired ability of the more adhesive cd34 Ϫ/Ϫ cells to cross intact endothelial barriers en route to BM stem cell niches (Figure 1E).Conversely, irradiation-induced vascular permeability facilitates migration of cd34 Ϫ/Ϫ HSCs into subvascular spaces, thereby explaining their favorable competition with wt cells for engraftment in preconditioned recipients.These data serve to highlight the importance of evaluating the ability of mutant and wild-type HSCs to engraft both irradiated and nonirradiated recipients, particularly when a mutation may influence the mobility or trafficking of stem cells.Approval for these studies was obtained from the University of British Columbia Animal Care Committee.

Source: Blood

DOI: 10.1182/blood-2007-03-080374