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Cloning of a mammalian elk potassium channel gene and EAG mRNA distribution in rat sympathetic ganglia

Year: 1998
Type: article
Abstract: 1. Three new members of the EAG potassium channel gene family were identified in rat and the complete coding sequence of one of these genes (elk1) was determined by cDNA cloning. 2. The elk1 gene, when expressed in Xenopus oocytes, encodes a slowly activating and slowly deactivating potassium channel. 3. The elk1 gene is expressed in sympathetic ganglia and is also expressed in sciatic nerve. 4. Six of the seven known EAG genes were found to be expressed in rat sympathetic ganglia, suggesting an important functional role for these channels in the sympathetic nervous system.
DOI: 10.1111/j.1469-7793.1998.675bg.x
Authors: Wenmei Shi, Hong‐Sheng Wang, Zongming Pan, Randy S. Wymore, Ira S. Cohen, David McKinnon, Jane E. Dixon
Language: English
Open Access status: green
Awards: TROPHIC CONTROL OF ELECTROPHYSIOLOGICAL PHENOTYPE, G3628949866, G4481860625, CARDIAC ELECTROPHYSIOLOGY: EFFECTS OF IONS AND DRUGS, CARDIAC ELECTROPHYSIOLOGY--EFFECTS OF IONS AND DRUGS, Molecular Physiology--Control of Firing Properties, G985837625
OpenAlex ID: W2066124606
FWCI: 2.214
Cites: 24
Cited by: 52
Related to: 10