Work

Basic and Clinical Immunology of Siglecs

Year: 2008

Type: review

Abstract: Siglecs are cell-surface proteins found primarily on hematopoietic cells. By definition, they are members of the immunoglobulin gene super-family and bind sialic acid. Most contain cytoplasmic tyrosine motifs implicated in cell signaling. This review will first summarize characteristics common and unique to Siglecs, followed by a discussion of each human Siglec in numerical order, mentioning in turn its closest murine ortholog or paralog. Each section will describe its pattern of cellular expression, latest known immune functions, ligands, and signaling pathways, with the focus being predominantly on CD33-related Siglecs. Potential clinical and therapeutic implications of each Siglec will also be covered.

Source: Annals of the New York Academy of Sciences

DOI: 10.1196/annals.1443.011

Authors: Stephan Von Gunten, Bruce S. Bochner

Institutions: Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Glycosylation and Glycoproteins Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Dana Foundation, Johns Hopkins University, National Institute of Allergy and Infectious Diseases