Work

Second-harmonic optical coherence tomography

Year: 2004

Type: article

Abstract: Second-harmonic optical coherence tomography, which uses coherence gating of second-order nonlinear optical responses of biological tissues for imaging, is described and demonstrated. Femtosecond laser pulses were used to excite second-harmonic waves from collagen harvested from rat tail tendon and a reference non-linear crystal. Second-harmonic interference fringe signals were detected and used for image construction. Because of the strong dependence of second-harmonic generation on molecular and tissue structures, this technique imparts contrast and resolution enhancement to conventional optical coherence tomography.

Source: Optics Letters

DOI: 10.1364/ol.29.001090

Authors: Yi Jiang, Ivan Tomov, Yimin Wang, Zhongping Chen

Institution: University of California, Irvine

Language: English

Topic: Optical Coherence Tomography Applications

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, Centers for Disease Control and Prevention, National Institute of Biomedical Imaging and Bioengineering, National Center for Research Resources

Awards: G201252989, G3640713170, Fourier Domain Functional OCT, A Laser Microbeam Biotechnology Resource, G6710541102