c-kit is not expressed in Hodgkin disease and anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma
Year: 2003
Type: letter
Abstract: We previously addressed within-person variability for several coagulation and inflammation factors, including the research-based D-dimer assay used in the Longitudinal Investigation of Thromboembolism Etiology (LITE).3 For D-dimer, the index of individuality, or the degree to which an analyte varies over time in an individual relative to the population, was 0.63 (similar to a value of 0.44 for cholesterol).In order to measure D-dimer with the same intraindividual variation as cholesterol, 2 measurements would be needed.These intraindividual variability statistics are similar to those of the emerging cardiovascular disease risk marker, highsensitivity C-reactive protein, 3 now a widely used clinical test.Other investigators have also reported acceptable reliability of D-dimer measurement.4 Because we have not proposed that D-dimer testing be done in clinical settings on the basis of our findings, it would be premature to recommend a cutoff value to define elevated D-dimer, or a mode of investigation to assess apparently healthy subjects with very high values (more than 1000 ng/mL).Since D-dimer assessment is also currently being studied in risk assessment for predicting recurrent venous thrombosis, 5 its reproducibility in patients with previous thrombosis will require stringent assessment, as D-dimer in these patients may be higher than in healthy individuals.
Source: Blood
Institution: Institut für Hämatopathologie Hamburg
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2066338758