Work

Enzymatic Ligation Creates Discrete Multinanoparticle Building Blocks for Self-Assembly

Year: 2008

Type: article

Abstract: Enzymatic ligation of discrete nanoparticle-DNA conjugates creates nanoparticle dimer and trimer structures in which the nanoparticles are linked by single-stranded DNA, rather than by double-stranded DNA as in previous experiments. Ligation was verified by agarose gel and small-angle X-ray scattering. This capability was utilized in two ways: first, to create a new class of multiparticle building blocks for nanoscale self-assembly and, second, to develop a system that can amplify a population of discrete nanoparticle assemblies.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja8026746