Work

A consensus sequence for substrate hydrolysis by rhino virus 3C proteinase

Year: 1989

Type: article

Abstract: Kinetic constants were determined for the hydrolysis of a series of synthetic peptide substrates by recombinant rhinovirus (HRV 14) 3C proteinase. Systematic removal or replacement of individual residues indicated that the minimum sequence required for effective cleavage by the viral cysteine proteinase was P5-Val/Thr-P3-P2-Gln-Gly-Pro.

Source: FEBS Letters

DOI: 10.1016/0014-5793(89)81619-9

Authors: Audrey C. Long, David C. Orr, Janet M. Cameron, Ben M. Dunn, John Kay

Institutions: University of Wales, University of Florida

Language: English

Topic: Protease and Inhibitor Mechanisms

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W2066561499

FWCI: 0.413

Cites: 7

Cited by: 42

Related to: 10