Targeting paediatric acute lymphoblastic leukaemia: novel therapies currently in development
Year: 2010
Type: review
Abstract: Modifications to the treatment of acute lymphoblastic leukaemia (ALL) in children have led to a dramatic increase in survival in the past 40 years. Despite this success, a significant subset of paediatric leukaemia patients either relapse or fail to ever achieve a complete remission. Additionally, some patients necessitate treatment with intensified chemotherapy regimens due to clinical or laboratory findings which identify them as high risk. These patients are unlikely to respond to further minor adjustments to the dosing or timing of administration of the same chemotherapy medications. Many novel targeted therapies for the treatment of childhood ALL provide potential mechanisms to further improve cure rates, and provide the possibility of minimizing toxicity to non-malignant cells, given their specificity to malignant cell phenotypes. This article explores many of the potential targeted therapies in varying stages of development, from those currently in clinical trials to those still being refined in the research laboratory.
Source: British Journal of Haematology
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: Damon Runyon Cancer Research Foundation, Uniting Against Lung Cancer, St. Baldrick's Foundation, Lung Cancer Research Foundation, Gabrielle's Angel Foundation for Cancer Research, National Institutes of Health, Cancer Center, University of Colorado, National Cancer Institute, Eunice Kennedy Shriver National Institute of Child Health and Human Development
OpenAlex ID: W2066616843