Work

Toll-like Receptors and Type I Interferons

Year: 2007

Type: review

Abstract: Toll-like receptors (TLRs) are key molecules of the innate immune systems, which detect conserved structures found in a broad range of pathogens and trigger innate immune responses. A subset of TLRs recognizes viral components and induces antiviral responses. Whereas TLR4 recognizes viral components at the cell surface, TLR3, TLR7, TLR8, and TLR9 recognize viral nucleic acids on endosomal membrane. After ligand recognition, these members activate their intrinsic signaling pathways and induce type I interferon. In this review, we discuss the recent findings of the viral recognition by TLRs and their signaling pathways.

Source: Journal of Biological Chemistry

DOI: 10.1074/jbc.r700009200

Authors: Satoshi Uematsu, Shizuo Akira

Institutions: Research Institute for Microbial Diseases, The University of Osaka, The University of Osaka, Japan Science and Technology Agency

Language: English

Topic: Immune Response and Inflammation

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,430