Year: 2014
Type: article
Abstract: This paper reports a facile and robust mold-templated technique for the assembly of mesoporous silica (MS) supraparticles and demonstrates their potential as vehicles for codelivery of brain-derived neurotrophic factor (BDNF) and dexamethasone (DEX). The MS supraparticles are assembled using gelatin as a biodegradable adhesive to bind and cross-link the particles. Microfabricated molds made of polydimethylsiloxane are used to control the size and shape of the supraparticles. The obtained mesoporous silica-gelatin hybrid supraparticles (MSG-SPs) are stable in water as well as in organic solvents, such as dimethyl sulfoxide, and efficiently coencapsulate both BDNF and DEX. The MSG-SPs also exhibit sustained release kinetics in simulated physiological conditions (>30 days), making them potential candidates for long-term delivery of therapeutics to the inner ear.
Source: Biomacromolecules
DOI: 10.1021/bm501171j
Institutions: The University of Melbourne, Bionics Institute
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
Awards: Nanoengineered Polymeric Materials for Environmental and Biological Applications, Nanoparticle based neurotrophin delivery, Engineering materials for advances in nanomedicine, Nanoengineered drug delivery to the inner ear to prevent progressive hearing loss, ARC Centre of Excellence in Convergent Bio-Nano Science and Technology
OpenAlex ID: W2066985863