Work

Physically Associated Synthetic Hydrogels with Long‐Term Covalent Stabilization for Cell Culture and Stem Cell Transplantation

Year: 2011

Type: article

Abstract: Poly(ethylene glycol)-poly(propylene sulfide) (PEG-PPS) hydrogels are injectable synthetic non-protease degradable hydrogels that allow cell spreading and proliferation in vitro and cellular infiltration in vivo. Further, this hydrogel promotes the survival of transplanted neural progenitor cells in the brain. PEG-PPS hydrogels form through a combination of hydrophobic interactions between the PPS domains and covalent bonds through disulfide exchange reactions of the polymer end groups.

Source: Advanced Materials

DOI: 10.1002/adma.201103349

Authors: Jianjun Zhang, Talar Tokatlian, Jin Zhong, Quinn K. T. Ng, Michaela Patterson, William E. Lowry, S. Thomas Carmichael, Tatiana Segura

Institution: University of California, Los Angeles

Language: English

Topic: Hydrogels: synthesis, properties, applications

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Science Foundation, National Institutes of Health, National Institute of General Medical Sciences, National Institute of Biomedical Imaging and Bioengineering

Awards: Biomaterials for Cell Triggered Gene Transfer, Biotechnology Training in Biomedical Sciences and Engineering, Understanding the Role of the Extracellular Matrix on Non-viral Gene Transfer

OpenAlex ID: W2067314629

FWCI: 1.025

Cites: 35

Cited by: 57

Related to: 10