Year: 1995
Type: article
Study design: Observational Study
Abstract: Correspondence to : Eduardo De Stefani, Registro Nacional de Cancer, Avenida Brasil 3080 dep. 402, Montevideo, Uruguay Abstract Objective -To examine the association between non-melanoma skin cancer and cigarette smoking. Design Hospital-based case-control study covering the period 1988-93. Subjects A total of 132 patients (73 with basal cell carcinoma and 59 with squamous cell carcinoma), and 395 age frequency matched controls with diseases unrelated to tobacco use. Main outcome measures Odds ratios (ORs) for non-melanoma skin cancer, according to smoking status, after con trolling for age, residence, education, and occupational sun exposure through un conditional logistic regression. Results -The OR was significantly higher in current cigarette smokers rela tive to never-smokers (OR = 2.1, 95% confidence interval (CI) = 1.1 to 3.9). A significant dose-response relation was observed for smoking duration (p for trend = 0.002). The OR for ever-smokers of long duration (50 years or more) was 2.3 (95% CI = 1.2 to 4.5). Higher risks were observed among current smokers (compared with former smokers) and among patients with squamous cell car cinoma (compared with those with basal cell carcinoma). Conclusions Although bias cannot be excluded completely, the positive associ ation between cigarette smoking and non melanoma skin cancer in our study supports the evidence from previous studies of a relationship between tobacco smoking and skin cancer. If these findings are replicated in population-based studies, estimates of the number of tobacco-related cancers would be en larged.
Source: Tobacco Control
DOI: 10.1136/tc.4.2.175
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2067407609