Work

Prospective multicentre study of the effect of voluntary plasmapheresis on plasma cholesterol levels in donors

Year: 2013

Type: article

Abstract: BACKGROUND AND OBJECTIVES: LDL apheresis is used to treat patients with familial hypercholesterolaemia, and low-volume plasmapheresis for plasma donation may similarly lower cholesterol levels in some donors. This study was designed to assess the effect of plasmapheresis on total, LDL and HDL cholesterol levels in a plasma donor population. MATERIALS AND METHODS: This was a prospective, unblinded longitudinal cohort study in which a blood sample was obtained for analysis before each donation. Data from 663 donors were analysed using a multivariable repeated measures regression model with a general estimating equations approach with changes in cholesterol as the primary outcome measure. RESULTS: The model predicted a significant decrease in total and LDL cholesterol for both genders and all baseline cholesterol levels (P < 0.01). The greatest total cholesterol decreases (women, -46.8 mg/dL; men, -32.2 mg/dL) were associated with high baseline levels and 2-4 days between donations. Small but statistically significant increases (P ≤ 0.01) in HDL cholesterol were predicted for donors with low baseline levels. CONCLUSIONS: These results suggest that, in donors with elevated baseline cholesterol levels, total and LDL cholesterol levels may decrease during routine voluntary plasmapheresis.

Source: Vox Sanguinis

DOI: 10.1111/vox.12031

Authors: M. Rosa‐Bray, C. Wisdom, S. Wada, B. R. Johnson, V. Grifols‐Roura, V. Grifols‐Lucas

Institutions: Grifols (United States), Westat (United States), Grifols (Spain)

Language: English

Topic: Blood donation and transfusion practices

Subfield: Management of Technology and Innovation

Field: Business, Management and Accounting

Domain: Social Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Lucas Foundation, Grifols