Year: 2013
Type: article
Study design: Observational Study
Abstract: BACKGROUND AND PURPOSE: Understanding the relationship between brain and behavior in early childhood requires a probe of functional brain development. We report the first large study of regional CBF by use of arterial spin-labeling in young children. MATERIALS AND METHODS: Cerebral blood flow by use of arterial spin-labeling was measured in 61 healthy children between the ages of 3 and 5 months. Blood flow maps were parcellated into 8 broadly defined anatomic regions of each cerebral hemisphere. RESULTS: There was no sex effect; however, group analysis demonstrated significantly greater CBF in the sensorimotor and occipital regions compared with dorsolateral prefrontal, subgenual, and orbitofrontal areas (P < .0001). A significant age effect was also identified, with the largest increase in blood flow between 3 and 5 months occurring in the following regions: orbitofrontal (P < .009), subgenual (P < .002), and inferior occipital lobe (P = .001). CONCLUSIONS: These results are consistent with prior histologic studies demonstrating regional variation in brain maturation and suggest that arterial spin-labeling is sensitive to regional as well as age-related differences in CBF in young children.
DOI: 10.3174/ajnr.a3728
Authors: A.F. Duncan, A. Caprihan, E.Q. Montague, J. Lowe, R. Schrader, J.P. Phillips
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: University of New Mexico Clinical and Translational Science Center, G222768804, RESEARCH AND DEVELOPMENT OF BETTER DIAGNOSIC TOOLS FOR MENTAL ILLNESS, NEUROLOGICAL DISORDERS, TRAUMATIC BRAIN INJURY AND POST TRAUMATIC STRESS DISOR, MRN: MISSION OF DISCOVERY AND ADVANCEMENT OF CLINICAL SOLUTIONS FOR THE PREVENTION, DIAGNOSIS, AND TREATMENT OF MENTAL ILLNESS AND OTHER BRAIN DISOR
OpenAlex ID: W2067486061