Work

In vivotracking of cellular therapeutics using magnetic resonance imaging

Year: 2009

Type: review

Abstract: BACKGROUND: The success of many cell-based therapies is highly dependent on the accurate delivery, dosing and trafficking of the cellular therapeutic. In vivo magnetic resonance (MR) cell tracking provides a means to non-invasively and longitudinally evaluate these parameters for cellular therapy. OBJECTIVE: To provide an overview of MR cell tracking and how cellular therapeutics might be improved by utilizing this technology. METHODS: We focused on the technologies utilized for stem cell and immunotherapies in preclinical models of disease. RESULTS/CONCLUSION: New technologies in MR cell tracking will soon take the field beyond preclinical studies and begin to show benefits in clinical trials of novel experimental cell-based therapies.

Source: Expert Opinion on Biological Therapy

DOI: 10.1517/14712590802715723

Authors: Christoper M Long, Jeff WM Bulte

Institutions: Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Mesenchymal stem cell research

Subfield: Genetics (clinical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute on Drug Abuse, National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering